General
Research Publications
Michelson Diagnostics' Multi-Beam Optical Coherence Tomography technology is now being used by research institutions and collaborators in the USA and Europe.
Details of the Michelson OCT Research Program can be downloaded here.
Published papers, articles and conference presentations are listed below under the following headings:
Clinical Dermatology
Christina Banzhaf, Gregor B.E. Jemec, "Imaging Granulomatous Lesions with Optical Coherence Tomography" Case Reports in Dermatology Vol. 4, Pages 14-18, 2012 See article.
Rebecca Pomerantza, Deborah Zell, Gordon McKenzie, Daniel M. Siegel "Optical Coherence Tomography Used as a Modality to Delineate Basal Cell Carcinoma prior to Mohs Micrographic Surgery" Case Reports in Dermatology Vol. 3, Pages 212-218, 2011 See article.
Sibel Zehra Aydin, Zoe Ash, Francesco Del Galdo, Helena Marzo-Ortega, Richard J. Wakefield, Paul Emery, Dennis McGonagle "Optical Coherence Tomography: A New Tool to Assess Nail Disease in Psoriasis?" Dermatology Vol. 222, No. 4, 2011 See article.
D. Cunha, T. Richardson, N. Sheth, G. Orchard, A. Coleman and R. Mallipeddi "Comparison of ex vivo optical coherence tomography with conventional frozen-section histology for visualizing basal cell carcinoma during Mohs micrographic surgery" British Journal of Dermatology Volume 165, September 2011, Pages 576-580 See article.
Lotte Themstrup, Mette Mogensen, G.B.E. Jemec "Optical Coherence Tomography Used for Monitoring of PDT Treatment of Superficial Basal Cell Carcinomas" Presented at 22nd World Congress of Dermatology May 2011 See presentation
Zaid Hamdoon "Optical coherence tomography - guided photodynamic therapy for skin cancer" Presented at the 13th IPA World Congress Innsbruck, Austria, 10-14th May 2011 See presentation
Zaid Hamdoon, Waseem Jerjes, Tahwinder Upile and Colin Hopper "Optical coherence tomography-guided photodynamic therapy for skin cancer: Case study" Photodiagnosis and Photodynamic Therapy Volume 8, Issue 1, March 2011, Pages 49-52 See article
D. Cunha, T. Richardson, N. Sheth, G. Orchard, A. Coleman and R. Mallipeddi "Comparison of ex vivo optical coherence tomography with conventional frozen-section histology for visualizing basal cell carcinoma during Mohs micrographic surgery" British Journal of Dermatology 2010 163 (Suppl. 1), pp101-117 See paper
Konig, K et al "Clinical optical coherence tomography combined with multiphoton tomography for evaluation of several skin disorders" Ed. J. A. Izatt, et al. Vol. 7554, 75542I (2010). Poster presented at Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV, SPIE See abstract
Konig, K et al (2009) "Clinical optical coherence tomography combined with multiphoton tomography of patients with skin diseases" Journal of Biophotonics, 2(6-7), pp. 389-397 Jul 2009 See abstract
Maxillofacial and Dental
Oluyori Kutulola Adegun, Pete H. Tomlins, Eleni Hagi-Pavli, Gordon Mckenzie, Kim Piper, Dan L. Bader and Farida Fortune "Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues" Lasers in Medical Science, Online First 18 August 2011, See article
Tomlins et al "Scattering attenuation microscopy of oral epithelial dysplasia" Journal of Biomedical Optics 15(06), 0660031 See abstract
Barr H, et al., "Rapid endoscopic identification and destruction of degenerating Barrett's mucosal neoplasia" The Surgeon (2010), doi:10.1016/j.surge.2010.08.003
SA Razzak et al "Optical Coherence Tomography (OCT) and the Incipient Carious Lesion" IADR General Session July 14-17, 2010, Barcelona See abstract
Jerjes, W et al "In vitro examination of suspicious oral lesions using optical coherence tomography" British Journal of Oral and Maxillofacial Surgery Volume 48, Issue 1, January 2010, Pages 18-25 See abstract
Hamdoon, Z et al "Immediate ex vivo optical coherence tomography of suspicious oral lesions" British Journal of Oral and Maxillofacial Surgery Volume 47, Issue 7, October 2009, Pages e51-e52 See abstract
Jerjes, W., et al "Oral leukoplakia and erythroplakia subjected to optical coherence tomography: preliminary results" British Journal of Oral & Maxillofacial Surgery Volume 46, Issue 7, 2009, Page e7
Ann Sandison et al "Detection of Oral Pathologies Using Optical Coherence Tomography" Touch Oncology, 2008 See article
Marcauteanu, C et al "Noninvasive Alternative Techniques for the Early Detection of Occlusal Overload" European Cells and Materials Vol. 16. Suppl. 5, 2008 (page 5) See paper
Bazant-Hegemark F, Stone N, McKenzie G and Holmes J. "Optical Coherence Tomography aids cancer detection" Biophotonics International, November 2007; 467
Download pdfTissue engineering
Smith LE, Bonesi M, Smallwood R, Matcher SJ, Macneil S."Using swept-source optical coherence tomography to monitor the formation of neo-epidermis in tissue-engineered skin" J Tissue Eng Regen Med. 2010 Jul 5 See abstract
Non-clinical Dermatology
Thakur Raghu Raj Singh, Martin J. Garland, Katarzyna Migalska, Ester Caffarel Salvador, Rahamatullah Shaikh, Helen O. McCarthy, A. David Woolfson, Ryan F. Donnelly "Influence of a pore-forming agent on swelling, network parameters, and permeability of poly(ethylene glycol)-crosslinked poly(methyl vinyl ether-co-maleic acid) hydrogels: Application in transdermal delivery systems" Journal of Applied Polymer Science, Early View Online, January 30 2012, See abstract
Donnelly, R F et al "Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution" Journal of Controlled Release (2010) doi:10.1016/j.jconrel.2010.08.008 See abstract
Donnelly, R F et al "Design, Optimization and Characterisation of Polymeric Microneedle Arrays Prepared by a Novel Laser-Based Micromoulding Technique" Journal of Pharmaceutical Research 19 May 2010 DOI 10.1007/s11095-010-0169-8 See abstract
Bazant-Hegemark, F et al "Multi-beam resolution video-rate swept-source optical coherence tomography (OCT) provides endogenous contrast for in vivo blood flow independent of flow direction" Ed. J. A. Izatt, et al. Vol. 7554, 75542Z (2010). Poster presented at Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV, SPIE See abstract
Mohammad R. N. Avanaki and Ali Hojjat "Speckle reduction with attenuation compensation for Skin OCT images enhancement" Presented at Medical Image Understanding & Analysis 15 July 2009
Non-clinical Scientific
Gerald W. Dorn II et al "MARF and Opa1 Control Mitochondrial and Cardiac Function in Drosophila" Circ Res.2010; 0: CIRCRESAHA.110.236745v1 See abstract
Dr Beau Standish et al "In-vivo endoscopic multi-beam optical coherence tomography" Phys. Med. Biol. 55 (2010) 615-622 See article
Jon Holmes. "In vivo real-time optical coherence tomography imaging of Drosophila for cardiovascular research" Nature Methods, October 2009, Volume 6 No 10 p iii-iv See article
Florian Bazant-Hegemark, Gordon McKenzie, Simon Hattersley, Jon Holmes. "Decorrelation of Dynamic Speckle as Endogenous Contrast for Vascular Flow in Video-Rate Multi-Beam Resolution Swept-Source Optical Coherence Tomography (OCT)" Presented at MICCAI Workshop on Optical Tissue Image analysis in Microscopy, Histopathology and Endoscopy Imperial College London September 24th 2009 See paper
Technology
J. Rasakanthan et al, "Quantitative Optical Coherence Tomography for Characterization of Microscopic Structures with Varying Refractive Index" in CLEO/Europe and EQEC 2011 Conference Digest, OSA Technical Digest (CD) (Optical Society of America, 2011), paper CH3_3 See abstract
P D Woolliams and P H Tomlins. "The modulation transfer function of an optical coherence tomography imaging system in turbid media" 2011 Phys. Med. Biol. 56 2855 doi: 10.1088/0031-9155/56/9/014 See abstract
Zenghai Lu, Deepa K. Kasaragod, and Stephen J. Matcher "Performance comparison between 8- and 14-bit-depth imaging in polarization-sensitive swept-source optical coherence tomography" Biomedical Optics Express, Vol. 2, Issue 4, pp. 794-804 (2011) See abstract
Zenghai Lu, Deepa K Kasaragod and Stephen J Matcher "Optic axis determination by fibre-based polarization-sensitive swept-source optical coherence tomography" 2011 Phys. Med. Biol. 56 1105 doi: 10.1088/0031-9155/56/4/014 See abstract
Alex Grimwood et al "Elastographic contrast generation in optical coherence tomography from a localized shear stress" 2010 Phys. Med. Biol. 55 5515 doi:10.1088/0031-9155/55/18/016 See abstract
Peter D. Woolliams, Robert A. Ferguson, Christian Hart, Alex Grimwood, and Peter H. Tomlins, "Spatially deconvolved optical coherence tomography," Appl. Opt. 49, 2014-2021 (2010) See abstract
Florian Bazant-Hegemark, Daniel Woods. "Optische Kohärenztomographie vom Forschungsgegenstand zum Forschungswerkzeug -BioPhotonik, März 2010, pp24-26 See article
Jon Holmes. "OCT technology development: Where are we now?" J. Biophoton. 1-9 (2009) / DOI 10.1002/jbio.200910014 See article
Holmes, Jon; Hattersley, Simon "Image blending and speckle noise reduction in multi-beam OCT" Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIII. Edited by Fujimoto, James G.; Izatt, Joseph A.; Tuchin, Valery V.. Proceedings of the SPIE, Volume 7168 (2009)., pp. 71681N-71681N-8 (2009)
Florian Bazant-Hegemark & Nicholas Stone "Towards automated classification of clinical optical coherence tomography data of dense tissues" Lasers in Medical Science Volume 24, Number 4, 627-638, DOI: 10.1007/s10103-008-0615-6 See abstract
Tomlins PH, Woolliams P, Hart C, Beaumont A, Tedaldi M."Optical coherence refractometry" Opt Lett. 2008 Oct 1;33(19):2272-4 See abstract
Holmes, J. (2008) "Theory and applications of Multi-Beam OCT" Eds. Podoleanu, A. Vol. 7139, pp. 713908-713907. Presented at 1st Canterbury Workshop on Optical Coherence Tomography and Adaptive Optics, SPIE, Canterbury, United Kingdom See abstract
J. Holmes, S. Hattersley, N. Stone, et al (2008) "Multichannel Fourier domain OCT system with superior lateral resolution for biomedical applications" Ed. J. A. Izatt, et al. Vol. 6847, pp. 68470O. Presented at Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII, SPIE
